Leena Bruckner-Tuderman Selected Research

Junctional Epidermolysis Bullosa (Epidermolysis Bullosa Letalis)

11/2016	Genotype, Clinical Course, and Therapeutic Decision Making in 76 Infants with Severe Generalized Junctional Epidermolysis Bullosa.
3/2014	The missense mutation p.R1303Q in type XVII collagen underlies junctional epidermolysis bullosa resembling Kindler syndrome.
1/2013	Laminin 332 in junctional epidermolysis bullosa.
12/2005	Molecular mechanisms of junctional epidermolysis bullosa: Col 15 domain mutations decrease the thermal stability of collagen XVII.
1/2005	Novel and recurrent mutations in the laminin-5 genes causing lethal junctional epidermolysis bullosa: molecular basis and clinical course of Herlitz disease.
6/2004	Keratinocytes from patients lacking collagen XVII display a migratory phenotype.
1/2004	Molecular consequences of deletion of the cytoplasmic domain of bullous pemphigoid 180 in a patient with predominant features of epidermolysis bullosa simplex.
12/2002	Molecular diagnostics facilitate distinction between lethal and non-lethal subtypes of junctional epidermolysis bullosa: a case report and review of the literature.
1/2002	Laminin 5 mutations in junctional epidermolysis bullosa: molecular basis of Herlitz vs. non-Herlitz phenotypes.

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Leena Bruckner-Tuderman Research Topics

Disease

26	Epidermolysis Bullosa Dystrophica (Dystrophic Epidermolysis Bullosa) 01/2022 - 01/2002
20	Bullous Pemphigoid (Pemphigoid) 05/2015 - 03/2003
12	Neoplasms (Cancer) 01/2021 - 07/2003
11	Epidermolysis Bullosa 06/2019 - 12/2002
10	Fibrosis (Cirrhosis) 01/2022 - 04/2011
10	Inflammation (Inflammations) 06/2019 - 09/2009
9	Wounds and Injuries (Trauma) 11/2020 - 01/2002
9	Junctional Epidermolysis Bullosa (Epidermolysis Bullosa Letalis) 11/2016 - 01/2002
8	Skin Diseases (Skin Disease) 01/2017 - 04/2005
6	Epidermolysis Bullosa Simplex (Epidermolysis Bullosa Herpetiformis Dowling Meara) 06/2019 - 01/2002
6	Pemphigus (Pemphigus Vulgaris) 01/2019 - 05/2008
6	Blister (Bulla) 11/2014 - 12/2006
5	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2018 - 07/2003
4	Poikiloderma of Kindler 12/2016 - 01/2004
4	Epidermolysis Bullosa Acquisita (Acquired Epidermolysis Bullosa) 04/2012 - 06/2003
3	Disease Progression 01/2019 - 01/2005
3	Carcinoma (Carcinomatosis) 03/2015 - 07/2003
2	Cicatrix (Scar) 01/2022 - 01/2002
2	Congenital Abnormalities (Deformity) 01/2019 - 05/2008
2	Carcinogenesis 02/2016 - 07/2003
2	Eosinophilia 05/2015 - 05/2007
2	Palmoplantar Keratoderma (Keratosis Palmaris et Plantaris) 03/2015 - 05/2011
2	Inborn Genetic Diseases (Disease, Hereditary) 07/2014 - 10/2012
2	Linear IgA Bullous Dermatosis 03/2014 - 07/2009
2	Atrophy 11/2011 - 10/2009
2	Leg Ulcer 09/2010 - 07/2006
2	Muscular Dystrophies (Muscular Dystrophy) 03/2010 - 04/2004
2	Atopic Dermatitis (Atopic Eczema) 07/2008 - 04/2005
2	Vesiculobullous Skin Diseases (Subcorneal Pustular Dermatosis) 05/2008 - 04/2006
2	Hypereosinophilic Syndrome (Loeffler Endocarditis) 05/2007 - 01/2006
1	Foot Deformities (Foot Deformity) 01/2019
1	Wound Infection (Wound Infections) 01/2018
1	Squamous Cell Carcinoma of Head and Neck 01/2018
1	Pityriasis Rubra Pilaris 11/2016
1	Papilloma (Papillomatosis) 02/2016

Drug/Important Bio-Agent (IBA)

34	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2002
20	Collagen Type XVIIIBA 01/2018 - 01/2002
19	CollagenIBA 01/2022 - 01/2002
17	AutoantibodiesIBA 01/2019 - 03/2003
12	Collagen Type VIIIBA 01/2019 - 06/2003
6	IntegrinsIBA 01/2021 - 11/2011
6	AntigensIBA 03/2012 - 12/2002
5	Keratins (Keratin)IBA 06/2019 - 01/2002
5	AntibodiesIBA 01/2012 - 12/2002
5	AutoantigensIBA 10/2010 - 01/2008
4	ProteomeIBA 10/2021 - 09/2010
4	Messenger RNA (mRNA)IBA 01/2018 - 11/2004
4	EpitopesIBA 05/2015 - 03/2003
4	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2013 - 01/2002
3	Dapsone FDA Link 01/2019 - 03/2009
3	Immunoglobulin G (IgG)IBA 01/2019 - 05/2011
3	Immunoglobulin E (IgE)IBA 05/2015 - 05/2011
3	Ointments (Pastes)IBA 03/2014 - 04/2005
3	KalininIBA 01/2013 - 01/2002
3	CytokinesIBA 04/2011 - 05/2009
3	Tacrolimus (Prograf)FDA LinkGeneric 01/2010 - 04/2005
2	Desmoglein 3IBA 01/2019 - 01/2010
2	Rituximab (Mabthera)FDA Link 01/2019 - 05/2008
2	SteroidsIBA 01/2019 - 03/2014
2	Biological ProductsIBA 01/2018 - 10/2009
2	Complement System Proteins (Complement)IBA 12/2017 - 03/2012
2	Nonsense Codon (Nonsense Mutation)IBA 01/2017 - 01/2004
2	Desmoplakins (Desmoplakin)IBA 03/2015 - 10/2012
2	Laminin (Merosin)IBA 03/2015 - 11/2004
2	Immunoglobulin A (IgA)IBA 03/2014 - 05/2011
2	LigandsIBA 06/2012 - 04/2006
2	Peptides (Polypeptides)IBA 02/2011 - 10/2010
2	PlectinIBA 03/2010 - 04/2004
2	Mycophenolic Acid (Cellcept)FDA LinkGeneric 01/2010 - 03/2009
2	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2010 - 03/2009
2	Azathioprine (Imuran)FDA LinkGeneric 01/2010 - 03/2009
2	Adrenal Cortex Hormones (Corticosteroids)IBA 03/2009 - 07/2008
2	Imatinib Mesylate (Gleevec)FDA Link 05/2007 - 01/2006
2	ProcollagenIBA 09/2002 - 07/2002
1	Matrix Metalloproteinases (MMPs)IBA 01/2021
1	Thrombospondin 1IBA 01/2021
1	Ligases (Synthetase)IBA 01/2021
1	Protein AggregatesIBA 06/2019
1	4-phenylbutyric acid (Buphenyl)FDA Link 06/2019
1	Keratin-5 (Keratin 5)IBA 06/2019
1	DecorinIBA 01/2019
1	Immunosuppressive Agents (Immunosuppressants)IBA 01/2019
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2019
1	APOBEC DeaminasesIBA 01/2018
1	RNA (Ribonucleic Acid)IBA 01/2018
1	amlexanox (Aphthasol)FDA Link 01/2017
1	AntioxidantsIBA 12/2016
1	secukinumabIBA 11/2016
1	Protein-Lysine 6-Oxidase (Lysyl Oxidase)IBA 02/2016
1	CarcinogensIBA 02/2016
1	Sirolimus (Rapamycin)FDA Link 01/2016
1	Interleukin-6 (Interleukin 6)IBA 09/2015
1	Losartan (Cozaar)FDA LinkGeneric 09/2015

Therapy/Procedure

19	Therapeutics 01/2022 - 09/2002
2	Injections 01/2022 - 01/2009
2	Intradermal Injections 11/2014 - 09/2009
2	Cell- and Tissue-Based Therapy (Cell Therapy) 11/2014 - 09/2009
1	Radiotherapy 01/2019
1	Precision Medicine 01/2017
1	Palliative Care (Palliative Therapy) 11/2016